GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7851726 | 1 | rs4385527 | chr9:97648587 | C9orf130 | chr9:98568372-98638259:- | -0.23 | -3.83 | 0.00015 | Urinary albumin-to-creatinine ratio |
| BLCA | cis | rs9457247 | 1 | rs439237 | chr6:167391392 | RNASET2 | chr6:167343008-167412795:- | -0.24 | -5.04 | 7.23E-7 | Crohn's disease |
| BLCA | cis | rs344081 | 1 | rs439295 | chr3:156572455 | LEKR1 | chr3:156544076-156763918:+ | -0.45 | -6.35 | 6.02E-10 | Bone mineral density |
| BLCA | cis | rs7655841 | 1 | rs4394010 | chr4:129894649 | C4orf33 | chr4:130014829-130033842:+ | 0.31 | 5.15 | 4.17E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs9457247 | 1 | rs439553 | chr6:167391212 | RNASET2 | chr6:167343008-167412795:- | -0.23 | -4.94 | 1.18E-6 | Crohn's disease |
| BLCA | cis | rs67073037 | 1 | rs4407214 | chr2:29118258 | TRMT61B | chr2:29072690-29093175:- | 0.33 | 5.06 | 6.67E-7 | Breast cancer (estrogen-receptor negative);Breast cancer |
| BLCA | cis | rs9815354 | 1 | rs4408846 | chr3:41753679 | ULK4 | chr3:41288091-42003660:- | 0.67 | 10.14 | 1.45E-21 | Diastolic blood pressure |
| BLCA | cis | rs10935120 | 1 | rs4417907 | chr3:134291363 | ANAPC13 | chr3:134196547-134204865:- | 0.51 | 8 | 1.45E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs4417907 | chr3:134291363 | CEP63 | chr3:134204575-134293852:+ | 0.24 | 4.14 | 4.32E-5 | Height |
| BLCA | cis | rs10935120 | 1 | rs4423809 | chr3:134300107 | ANAPC13 | chr3:134196547-134204865:- | -0.48 | -7.73 | 9.49E-14 | Height |
| BLCA | cis | rs9457247 | 1 | rs444988 | chr6:167389674 | RNASET2 | chr6:167343008-167412795:- | -0.24 | -4.96 | 1.04E-6 | Crohn's disease |
| BLCA | cis | rs9902453 | 1 | rs4465649 | chr17:28394747 | EFCAB5 | chr17:28256874-28435469:+ | -0.22 | -3.85 | 0.00014 | Coffee consumption (cups per day) |
| BLCA | cis | rs7655841 | 1 | rs4466058 | chr4:129923879 | C4orf33 | chr4:130014829-130033842:+ | -0.32 | -5.3 | 1.97E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs9473555 | 1 | rs4469291 | chr6:49440614 | CENPQ | chr6:49431096-49460820:+ | -0.28 | -5.56 | 4.93E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs4469291 | chr6:49440614 | MUT | chr6:49398994-49431031:- | 0.28 | 5.5 | 6.93E-8 | Folate pathway vitamin levels |